So how exactly does it work? The ECS seems to have two main components that interact with each other to exert its effects: While scientists are still trying to understand the specific mechanisms by which the ECS modulates each of these different effects, it has to do with the fact that the ECS modulates neurotransmission3 (i.e., nerve signaling), according to integrative medicine physician Robert Rountree, M.D. “The most common contributors to ECS deficiency are the usual suspects when it comes to poor health,” says Knox. “Unhealthy diet and nutritional deficiency, environmental toxins and chemical pollutants, mental and emotional stress, and the ways these factors interplay with the typical aging process.” Stress, for example, seems to throw the ECS out of whack by “activating enzymes that break these endocannabinoids down,” adds Rountree. Low levels of cannabinoids, in turn, have been associated with a variety of difficult-to-treat conditions6, “including migraines, fibromyalgia, irritable bowel syndrome, post-traumatic stress disorder, and seizure disorders,” says Knox. But how do you know if you’re dealing with endocannabinoid deficiency? Unfortunately, there’s no commercially available method to test someone’s endocannabinoid tone just yet. Generally feeling out of balance, or dealing with one of the chronic ailments above (especially if it doesn’t get better despite your best efforts) could be an indicator. For example, says Rountree, “if someone has chronic digestive issues or IBS, despite being cleared of the major culprits like inflammatory bowel disease or an infectious agent, then I think it’s a reasonable assumption this person could have a disorder of the endocannabinoid system.” But having a suboptimal ECS doesn’t mean you’re destined to experience poor health. In fact, this research has led to a growing interest in the use of phytocannabinoids (in the form of targeted supplements) to support the ECS and optimize overall health. The reason, it seems, is that phytocannabinoids, like those found in full-spectrum hemp oil extract, can interact with the ECS and its receptors similarly to our own endocannabinoids, helping bring the body back to a state of homeostasis.* Phytocannabinoids can influence the ECS in two ways, Rountree explains. “They either activate the receptors directly,” essentially acting like endocannabinoids themselves or “they block the enzymes that normally break down endocannabinoids,” which supports the production and preservation of the body’s own endocannabinoids. But don’t confuse a full-spectrum hemp oil supplement with a product containing isolated CBD extract, which neither Rountree nor Knox recommend. “A full-spectrum product is always preferred because it will most closely represent the phytochemical composition of the source plant,” says Knox. As research on the ECS grows, more experts are touting the potential benefit of incorporating hemp into your daily routine. “A full-spectrum hemp product essentially acts like a multivitamin for the endocannabinoid system,” says Carl Germano, R.D., CNS, CDN, clinical nutritionist and author of Road to Ananda.* In addition to a multivitamin, probiotic, omega-3, magnesium, and vitamin D, Germano believes hemp is one of the foundations of a good supplement protocol. These cannabimimetics include plenty of foods such as those containing omega-3 fatty acids, which are crucial building blocks in the formation of your own endocannabinoids. Think: wild-caught salmon or sardines, walnuts, and flax seeds (or a quality fish oil supplement). Some research even suggests that many of the anti-inflammatory benefits of consuming omega-3s can be attributed to their role in supporting the ECS. Other ECS-supporting foods include a variety of herbs and spices. Black pepper, cloves, and black cumin seeds all contain the phytocannabinoid beta-caryophyllene10, which acts directly on CB2 receptors to regulate the ECS and control inflammation and pain signaling. Small amounts of phytocannabinoids and cannabimimetic nutrients can also be found in carrots, echinacea, cacao, hops, thyme, and rosemary, says Germano. Additionally, almost anything that reduces stress (which, as mentioned earlier, can activate enzymes that break down your own endocannabinoids) supports the ECS. “Cannabimimetic practices11 include moderate exercise, deep breathing, yoga, acupuncture, massage, meditation, prayer, and almost any other mind-body therapeutic you can think of,” says Knox. “One of the most exciting things about the ECS is that its physiology is finally providing the biological basis for many ancient healing traditions.”
